This analysis summarizes studies comparing attained heights with expected heights of children with asthma treated with inhaled or oral corticosteroids. The possible moderating effects of treatment duration, and dosage and asthma severity are also examined.
Summary: Inhaled drugs are frequently given to infants and young children with a pressurized metered-dose inhaler (pMDI) attached to a valved-holding chamber (VHC) with face mask. In young children and infants who cannot breathe through a mouthpiece, the face mask serves as the interface be
BACKGROUND: In vitro assessments of VHC performance are primarily designed to characterize aerosol formulations during product development and to ensure consistent product quality, rather than predict how the device will perform when used by a patient.
Purpose: To compare the clinical efficacy and delivery time of nebulizer of beta agonist bronchodilator with the use of the AeroElipse® Breath Actuated Nebulizer (Monaghan Medical Corp.) as compared to the Airlife Misty-Neb Nebulizer (SVN) (Allegiance Healthcare Corporation).
BACKGROUND: Metered-dose inhalers with valved holding chambers (MDI-VHCs) have been shown to be equivalent to small-volume nebulizers (SVN’s) for the delivery of bronchodilators in children. At Seattle Children’s Hospital and Regional Medical Center we sought to implement the co
Electrostatic charge (ESC) on valved holding chambers (VHCs) decreases drug delivery while reducing ESC increases the amount of drug reaching the airways. However, there are no data on the clinical relevance of this finding in patients with acute bronchospasm.
BACKGROUND: Bronchodilator treatment for asthma can be provided with various aerosolgenerating
devices and methods. There have been no randomized trials of a breath-actuated nebulizer
versus continuous 1-hour nebulization and/or small-volume constant-output nebulizer in