Overcoming Electrostatic Charge Retention in a New Valved Holding Chamber (VHC): In Vitro Performance Comparison with Current Devices
Particle deposition caused by electrostatic attraction to the walls of VHCs made from non-conducting polymer can significantly reduce pressurized metered dose inhaler (pMDI) medication delivery, especially at first use. Washing in ionic detergent followed by drip-drying to coat the interior surfaces with a conducting layer of surfactant is effective at counteracting these losses, but the process is time consuming and therefore inconvenient, especially in the hospital setting. A new VHC (AeroChamber Max™, Trudell Medical International) has been designed in which the body is manufactured from an electrostatic dissipative but transparent custom polymer so that it can be used without pre-treatment. Aerosol formation is therefore visible to both health care giver and patient. VHC volume (198-ml) has also been chosen to optimize the delivery of medication. The design intent is to ensure that most of the aerosol delivered to the VHC at pMDI actuation remains suspended if a poorly coordinated patient delays inhalation for several seconds.
